![]() ![]() Fueron retirados y procesados los músculos diafragma, esternomastoideo, tibial anterior y gastrocnemio de acuerdo con los métodos de rutina histológica. ![]() Después de 60 días de tratamiento, un ml de sangre fue recogida para cuantificar la creatina quinasa (CK) de prueba. Los ratones mdx adultos machos y hembras (014/06-CEEA) se dividieron en control y cítricos tratados. El objetivo de este estudio fue comprobar el posible efecto protector, antiinflamatorio del aceite de cítricos en las fibras musculares mdx. Mdx ratones mutantes muestran una marcada deficiencia en la distrofina, que está relacionada con la estabilidad de la membrana muscular. RESUMEN: La distrofia muscular de Duchenne (DMD) es una enfermedad grave ligada al cromosoma X, trastorno recesivo que se caracteriza por la pérdida progresiva de fuerza muscular. mdx mouse, Muscle regeneration Central nuclei Creatine kinase. KEY WORDS: Muscle fiber Duchenne muscular dystrophy Citrus aurantium L. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. The observed alterations indicate a direct effect of citrus. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. ![]() SUMMARY: Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. ***Department of Physiology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu Municipality, São Paulo State, Brazil. ** Department of Anatomy, Institute of Biology, State University of Campinas (UNICAMP), Campinas Municipality, São Paulo State, Brazil. * Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu Municipality, São Paulo State, Brazil. *Paula Aiello Tomé De Souza **Maria Júlia Marques ***Clélia Akiko Hiruma Lima & **Selma Maria Michelin Matheus en la Regeneración Muscular en Ratones Mdx Essential Oil on Muscle Regeneration in Mdx MiceĮfecto del Aceite Esencial de Citrus aurantium L. ![]()
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